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The biological target of FOXO4-DRI is the FOXO4p53 protein-protein interaction a molecular axis identified as pivotal for maintaining the viability of senescent cells

SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1 positive feedback loop

Pat your skin until it's slightly damp--not bone-dry--since a bit of moisture helps water-based serums spread evenly

This counterintuitive finding suggested that while FOXO4 is involved in the senescence program, it also helps maintain the viability of senescent cells, potentially contributing to their accumulation [2]